5 Reasons For Obesity To Be A Cause Of Type 2 Diabetes

Reasons For Obesity To Be A Cause Of Type 2 Diabetes

Among the people diagnosed with type2 diabetes, approximately 80 to 90 percent of them are diagnosed as obese. Obesity affects both old and young people. One of the risk factors identified for the development of type 2 diabetes is overweight or obesity. As per the statistical evaluation of World Health Organization, approximately 2.8 million people die every year from obesity. Diabetes can be prevented by an overweight person with a small loss in weight. Weight loss can also delay in developing diabetes even of the person has higher risk of contracting this disease. Weight loss can prevent the development of common complications associated with diabetes or will reduce the amount of drugs used for treating the disease.

These Are Reasons For Obesity To Be A Cause Of Type 2 Diabetes

Genetic Susceptibility

Research studies have shown that variation in the TCF7L2 gene is allowing the individual to be susceptible to type2 diabetes. The individuals carrying two copies of this gene variant were known to have 80 percent higher risk of developing this disease than those who do not carry the variants of this gene. It was also found by the Diabetes Prevention Program or DPP that individuals with mutation in this gene experience delay in its expression, if they are practicing physical activity and diet. Genes are also found to be causing higher risk of diabetes when the person is overweight or obese. DPP has shown that risk for type2 diabetes was reduced by carrying out lifestyle changes and losing weight.

Genetic Susceptibility

Insulin Resistance

Insulin resistance is generally witnessed in obese people or those who have excess abdominal fat or by those who are not physically active. The cells in the liver, muscle and fat will stop reacting to insulin and pressurize the pancreas to produce more insulin. As long as insulin is produced normally by the beta cells, glucose levels in the blood remain in the normal levels.

Insulin Resistance

Metabolic Syndrome

Metabolic syndrome is observed in people who are suffering from group of conditions resulting from insulin resistance. The syndrome includes certain conditions like higher blood glucose levels, high blood pressure, increased abdominal fat and abnormal blood levels of triglycerides and cholesterol. Individuals suffering from metabolic syndrome are at greater risk of mounting type2 diabetes and cardiovascular disease. Making changes in the lifestyle like physically active and losing excess weight are a few ways of reversing metabolic syndrome, improving the response of the body to insulin and reducing the risk of type2 diabetes and cardiovascular disease. Reducing body weight can improve body’s sensitivity towards insulin and diminishes the threat of developing metabolic and cardiovascular conditions like type2 diabetes.

Metabolic Syndrome

Inflammatory Response

The abdominal fat deposition will release pro-inflammatory chemicals, which destroys the insulin responsive cell functioning. The body is made less sensitive to insulin and the cells show low response to insulin. This is called insulin resistance and is considered as a stimulant of type2 diabetes. Excess fat at the abdominal region is a form of obesity that is at higher risk for diabetes.

Powerful Anti-inflammatory Agent

Insulin Intake Gains Weight

People taking insulin for treating diabetes, naturally gain weight. As more insulin is taken for regulating blood glucose levels, high amount of glucose is engaged into the cells. This immersed glucose is deposited as fat in the cells and make you gain weight. A person diagnosed with diabetes has to also modify his or her diet to avoid gaining weight due to insulin intake. Otherwise, diabetes related complications might arise and the existing problem of high blood glucose will enhance.

Insulin Intake Gains Weight